• Users Online: 287
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2014  |  Volume : 1  |  Issue : 2  |  Page : 82-86

Sheehan's syndrome: A clinical, biochemical, hormonal, radiological, bone mineral density and quality of life assessment

1 Department of Endocrinology, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India
2 Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
3 Consultant Radiologist, Om Imaging, Meerut, Uttar Pradesh, India
4 Department of Endocrinology Medicine, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India

Correspondence Address:
Manish Gutch
D 15, Lala Lajpat Rai Memorial Medical College, Meerut 250 004, Uttar Pradesh
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2348-3334.134266

Rights and Permissions

Background: Sheehan's syndrome (SS) or postpartum pituitary necrosis though rare, still remains one of the commonest causes of hypopituitarism in the Indian subcontinent. The clinical presentation is often variable with abrupt or insidiously onset pituitary insufficiency after heavy intrapartum or postpartum hemorrhage. Aims: To study the demographic profile, hormonal profile, as well as the quality of life of patients of SS, and the effect of hormonal replacement therapy on outcome. Materials and Methods: All patients previously diagnosed with Sheehan's syndrome or newly admitted during the study period of 2011-2013 were enrolled in the study after obtaining informed consent. Their clinical, biochemical, hormonal, radiological and bone mineral density (BMD) data were collected. The quality of life (QoL) was assessed using the disease-specific questionnaire both before and after hormone replacement therapy. Result: Twenty three patients were enrolled in the study, the mean age of diagnosis was 43.4 ± 14.2 years; mean diagnostic delay was 13.2 ± 7.4 years. Secondary amenorrhea and lactation failure were the most common clinical presentations. The mean total tetraiodothyronine (T4), peak stimulated cortisol, stimulated growth hormone (GH), and prolactin (PRL) levels were low. The gonadotropins [follicle stimulating hormone (FSH) and luteinizing hormone (LH)] were inappropriately normal in the presence of amenorrhea. Anemia was the most common hematological abnormality seen in 69.5% of patients, while 39.1% of patients had hyponatermia. BMD assessment (n = 23) was suggestive of low bone mass. The QoL improved significantly (P < 0.05) in patients after one year of hormonal replacement therapy. Conclusion: Sheehan's syndrome resulted in multiple pituitary hormone deficiencies in all patients. Anemia, hyponatremia, and low bone mass were frequently seen in patients with Sheehan's syndrome. The QoL improved significantly (P < 0.05) after hormonal replacement therapy.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded374    
    Comments [Add]    

Recommend this journal