CHRISMED Journal of Health and Research

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 4  |  Issue : 2  |  Page : 81--86

Serum lipids in chronic viral hepatitis B patients in Makurdi, Nigeria


Ayu Agbecha1, Chinyere Adanna Usoro2, Maisie Henrietta Etukudo2 
1 Department of Chemical Pathology, Federal Medical Centre, Makurdi, Nigeria
2 Department of Medical Laboratory Science, Chemical Pathology Unit, University of Calabar, Calabar, Nigeria

Correspondence Address:
Ayu Agbecha
Department of Chemical Pathology, Federal Medical Centre, Makurdi
Nigeria

Background: One of the major causes of liver disease in the world is hepatitis B virus (HBV) infection. The liver as a homeostatic organ plays a pivotal role in maintaining the relative balance of lipid and lipoprotein metabolism in the body. Aim: The study aimed at determining the impact of chronic hepatitis B (CHB) disease on serum lipids and the effect of the stages of this disease on lipid pattern in infected patients. Methodology: The study involved the selection of 70 CHB patients attending clinic at a Tertiary Hospital in Makurdi, Nigeria. After fulfilling the inclusion criteria, 65 anthropometrically matched apparently healthy individuals were selected as control to the CHB group. CHB is defined in the study as persistent infection evidenced by seropositivity for hepatitis B surface antigen without remission for up to 1-year. Results: There was a significantly reduced (P = 0.001) high-density lipoprotein cholesterol (HDL-C) and raised (P = 0.044) low-density lipoprotein cholesterol (LDL-C) in chronic HBV compared to seronegative controls. There was a significantly lowered HDL-C (P = 0.017), very LDL-C (P = 0.005), and triglyceride (P = 0.034) in asymptomatic CHB compared to the matched controls. There was a significantly lowered total cholesterol (P = 0.019) and HDL-C (P = 0.017) in symptomatic CHB compared to the matched controls. Conclusion: Lowered serum lipids are associated with CHB disease and likely to be mediated altered liver metabolism. However, reasons for the low levels of lipids in this viral disease still remains unclear.


How to cite this article:
Agbecha A, Usoro CA, Etukudo MH. Serum lipids in chronic viral hepatitis B patients in Makurdi, Nigeria.CHRISMED J Health Res 2017;4:81-86


How to cite this URL:
Agbecha A, Usoro CA, Etukudo MH. Serum lipids in chronic viral hepatitis B patients in Makurdi, Nigeria. CHRISMED J Health Res [serial online] 2017 [cited 2017 Jul 21 ];4:81-86
Available from: http://www.cjhr.org/article.asp?issn=2348-3334;year=2017;volume=4;issue=2;spage=81;epage=86;aulast=Agbecha;type=0