CHRISMED Journal of Health and Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 1  |  Issue : 4  |  Page : 258--262

Th1/Th2 profile in patients suffering with osteoarthritis and rheumatoid arthritis: An analytical observational study


Yatendra Singh1, Shadab Ahmad Khan2, Mohammad Owais3, Mazhar Abbas4, Anjum Parvez2, Athar Kamal2 
1 Department of Medicine, Government Medical College, Haldwani, Uttarakhand, India
2 Department of Medicine, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, India
3 Department of Biotechnology, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
4 Department of Orthopaedics, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, India

Correspondence Address:
Dr. Yatendra Singh
Room No. 32, Sr Hostel, Government Medical College, Haldwani - 263 129, Uttarakhand
India

Aims: To compare the cytokine (Th1/Th2) profile in serum as well as in synovial fluid of patients suffering with osteoarthritis (OA) and rheumatoid arthritis (RA). Settings and Design: Hospital-based analytical observational study. Materials and Methods: The present study comprised of 70 patients of arthritis, out of which, 40 patients were patients suffering from RA and 30 patients suffering from OA. Patients fulfilling the revised ARA Criteria for the Classification of Rheumatoid Arthritis are diagnosed as a case of RA and recruited for this study. Patients fulfilling the clinical and radiological features of osteoarthritis included in the study. Cytokine assay estimated using Western Blot (Immuno-blot transfer). Statistical Analysis Used: Analysis was performed using SPSS version 16.0 Statistical package for windows (SPSS, Chicago, IL). Results: Arthritis is commonly seen in females than males. Proinflammatory cytokines (IL-1, IL-2 and IFN-γ), anti-inflammatory cytokines (IL-4 and IL-10), regulatory cytokine (TGF-β) of blood as well as serum levels were raised in RA patients as compared with OA patients (P < 0.01). Tumor necrosis factor (TNF-α), an proinflammatory cytokine, levels were also raised significantly in OA. Conclusions: Our study shows that both Th1 and Th2 cells derived inflammatory markers as well as levels of IL-1 and TNF-α (both blood as well as synovial fluid) were significantly raised in RA as compared with OA patients. Thus, high levels of these substances have been found in inflammatory arthropathies, in particular in those characterized by a more aggressive and destructive outcome, such as RA.


How to cite this article:
Singh Y, Khan SA, Owais M, Abbas M, Parvez A, Kamal A. Th1/Th2 profile in patients suffering with osteoarthritis and rheumatoid arthritis: An analytical observational study.CHRISMED J Health Res 2014;1:258-262


How to cite this URL:
Singh Y, Khan SA, Owais M, Abbas M, Parvez A, Kamal A. Th1/Th2 profile in patients suffering with osteoarthritis and rheumatoid arthritis: An analytical observational study. CHRISMED J Health Res [serial online] 2014 [cited 2020 Jul 11 ];1:258-262
Available from: http://www.cjhr.org/article.asp?issn=2348-3334;year=2014;volume=1;issue=4;spage=258;epage=262;aulast=Singh;type=0