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ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 3  |  Page : 218-222

Comparison of different stains in imprint cytology with the conventional diagnostic tools in detection of Helicobacter pylori infection


1 Department of Pathology, Sree Narayana Institute of Medical Sciences, Ernakulam, Kerala, India
2 Department of Microbiology, Sree Narayana Institute of Medical Sciences, Ernakulam, Kerala, India

Correspondence Address:
Dr. Shashikant Adlekha
Department of Pathology, Sree Narayana Medical college, Chalakka, Ernakulam, Kerala - 683 594
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2348-3334.158679

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Background: Helicobacter pylori (H. pylori) infection is one of the most common causes of gastrointestinal morbidity and mortality worldwide. Early diagnosis of infection is imperative for the cure of distressing symptoms and prevention of complications. Objective: The objective of the study is to evaluate imprint cytology of gastric biopsy specimens as a rapid and cost-effective diagnostic tool and its comparison with conventional diagnostic tests. Materials and Methods: Antral biopsies were collected from 130 patients and evaluated for H. pylori infection by imprint cytology and histopathological examination by different stains and rapid urease test (RUT). Histopathological features of gastric biopsy specimens were also assessed. Results: A total of 118 patients showed H. pylori infection by two or more methods. Giemsa histology showed highest sensitivity, specificity, positive predictive value, negative predictive value and Youden's Index (YI). Among imprint cytology stain methods, toluidine blue showed highest sensitivity and highest YI was obtained for PAP stain. Conclusion: Helicobacter pylori infection is associated with gastric mucosa changes like chronic active gastritis, atrophy, intestinal metaplasia, ulceration and carcinoma. Imprint cytology has high sensitivity and comparable predictive values to conventional diagnostic tools-histopathological examination and RUT in the detection of H. pylori infection.


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